Implications of Axillary Lymphadenopathy Following COVID-19 Vaccination for Breast Cancer Screening


Radiology, Mammogram, Axillary Lymphadenopathy, COVID-19, vaccination, Sonography

How to Cite

Jamal, S., Pingali, V. ., & Farooq, M. U. (2023). Implications of Axillary Lymphadenopathy Following COVID-19 Vaccination for Breast Cancer Screening: Systematic Review. The Physician, 8(3).


Aim: We conducted a systematic review to study cases of women who reported abnormalities on mammograms following COVID-19 vaccination, and evaluate the proportion of cases that warranted further investigations to rule out breast cancer. Through this, we aimed to evaluate the need for further follow-up radiological investigations such as sonography etc. before invasive investigations were carried out to rule out breast malignancy.


Methods: Electronic Databases of PubMed, and Medline were searched on 18th July 2022, to extract published articles with the keywords: COVID-19 vaccination, Lymphadenopathy, and Mammogram. The publication timeframe of included studies ranged from November 01, 2019, to July 18, 2022. Studies that were published in languages other than English were not considered for this systematic review. In vitro studies, In vivo studies, review articles and short communications were not considered for this systematic review. However, references of reviews were cross-checked for relevant publications.


Results: We identified 20 published results and 9 publications were selected after eliminating reviews, communication articles, and non-research articles 1048 patients were included in the systematic review. with 287 patients reporting significant abnormalities on mammography findings, which would warrant further invasive investigations according to NHS, UK protocols [9]


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